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Intraneuronal β-Amyloid Expression Downregulates the Akt Survival Pathway and Blunts the Stress Response
Early events in Alzheimer's disease (AD) pathogenesis implicate the accumulation of β-amyloid (Aβ) peptide inside neurons in vulnerable brain regions. However, little is known about the consequences of intraneuronal Aβ on signaling mechanisms. Here, we demonstrate, using an inducible viral vect...
Gespeichert in:
| Veröffentlicht in: | J Neurosci |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Society for Neuroscience
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6725865/ https://ncbi.nlm.nih.gov/pubmed/16306409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1723-05.2005 |
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