Intraneuronal β-Amyloid Expression Downregulates the Akt Survival Pathway and Blunts the Stress Response

Early events in Alzheimer's disease (AD) pathogenesis implicate the accumulation of β-amyloid (Aβ) peptide inside neurons in vulnerable brain regions. However, little is known about the consequences of intraneuronal Aβ on signaling mechanisms. Here, we demonstrate, using an inducible viral vect...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Magrané, Jordi, Rosen, Kenneth M., Smith, Roy C., Walsh, Kenneth, Gouras, Gunnar K., Querfurth, Henry W.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2005
Assuntos:
Neurobiology of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725865/
https://ncbi.nlm.nih.gov/pubmed/16306409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1723-05.2005
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