Development of a Femtomolar-Acting Humanin Derivative Named Colivelin by Attaching Activity-Dependent Neurotrophic Factor to Its N Terminus: Characterization of Colivelin-Mediated Neuroprotection against Alzheimer's Disease-Relevant Insults In Vitro and In Vivo

Alzheimer's disease (AD) is the most common cause of dementia. Humanin (HN) is a short bioactive peptide abolishing neuronal cell death induced by various familial AD (FAD)-causative genes and amyloid-β (Aβ) in vitro. It has been shown that HN suppresses memory impairment of mice induced by int...

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Pubblicato in:J Neurosci
Autori principali: Chiba, Tomohiro, Yamada, Marina, Hashimoto, Yuichi, Sato, Maiko, Sasabe, Jumpei, Kita, Yoshiko, Terashita, Kenzo, Aiso, Sadakazu, Nishimoto, Ikuo, Matsuoka, Masaaki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2005
Soggetti:
Neurobiology of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725789/
https://ncbi.nlm.nih.gov/pubmed/16267233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3348-05.2005
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