Fyn Kinase Induces Synaptic and Cognitive Impairments in a Transgenic Mouse Model of Alzheimer's Disease

Human amyloid precursor protein (hAPP) transgenic mice with high levels of amyloid-β (Aβ) develop behavioral deficits that correlate with the depletion of synaptic activity-related proteins in the dentate gyrus. The tyrosine kinase Fyn is altered in Alzheimer's disease brains and modulates prem...

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Vydáno v:J Neurosci
Hlavní autoři: Chin, Jeannie, Palop, Jorge J., Puoliväli, Jukka, Massaro, Catherine, Bien-Ly, Nga, Gerstein, Hilary, Scearce-Levie, Kimberly, Masliah, Eliezer, Mucke, Lennart
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2005
Témata:
Neurobiology of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725734/
https://ncbi.nlm.nih.gov/pubmed/16237174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2980-05.2005
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