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Inhibitors of the Mitogen-Activated Protein Kinase Kinase 1/2 Signaling Pathway Clear Prion-Infected Cells from PrP(Sc)

Prions represent a unique class of infectious agents in which the normal cellular prion protein (PrP(C)) is converted to an abnormal isoform (PrP(Sc)), which accumulates in the brain and constitutes the major, if not the only, component of the infectious particle. Factors that still remain to be ide...

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Detalles Bibliográficos
Publicado en:J Neurosci
Autores principales: Nordström, Elin K., Luhr, Katarina M., Ibáñez, Carlos, Kristensson, Krister
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2005
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725673/
https://ncbi.nlm.nih.gov/pubmed/16162927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2349-05.2005
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