Inhibitors of the Mitogen-Activated Protein Kinase Kinase 1/2 Signaling Pathway Clear Prion-Infected Cells from PrP(Sc)

Prions represent a unique class of infectious agents in which the normal cellular prion protein (PrP(C)) is converted to an abnormal isoform (PrP(Sc)), which accumulates in the brain and constitutes the major, if not the only, component of the infectious particle. Factors that still remain to be ide...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Nordström, Elin K., Luhr, Katarina M., Ibáñez, Carlos, Kristensson, Krister
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2005
Subjects:
Neurobiology of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725673/
https://ncbi.nlm.nih.gov/pubmed/16162927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2349-05.2005
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