Live imaging of prions reveals nascent PrP(Sc) in cell-surface, raft-associated amyloid strings and webs

Mammalian prions refold host glycosylphosphatidylinositol-anchored PrP(C) into β-sheet–rich PrP(Sc). PrP(Sc) is rapidly truncated into a C-terminal PrP27-30 core that is stable for days in endolysosomes. The nature of cell-associated prions, their attachment to membranes and rafts, and their subcell...

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Main Authors: Rouvinski, Alexander, Karniely, Sharon, Kounin, Maria, Moussa, Sanaa, Goldberg, Miri D., Warburg, Gabriela, Lyakhovetsky, Roman, Papy-Garcia, Dulce, Kutzsche, Janine, Korth, Carsten, Carlson, George A., Godsave, Susan F., Peters, Peter J., Luhr, Katarina, Kristensson, Krister, Taraboulos, Albert
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2014
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3912534/
https://ncbi.nlm.nih.gov/pubmed/24493590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201308028
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