Continuous Low-Level Glial Cell Line-Derived Neurotrophic Factor Delivery Using Recombinant Adeno-Associated Viral Vectors Provides Neuroprotection and Induces Behavioral Recovery in a Primate Model of Parkinson's Disease

The therapeutic potential of glial cell line-derived neurotrophic factor (GDNF) for Parkinson's disease is likely to depend on sustained delivery of the appropriate amount to the target areas. Recombinant adeno-associated viral vectors (rAAVs) expressing GDNF may be a suitable delivery system f...

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Bibliographische Detailangaben
Veröffentlicht in:J Neurosci
Hauptverfasser: Eslamboli, Andisheh, Georgievska, Biljana, Ridley, Rosalind M., Baker, Harry F., Muzyczka, Nicholas, Burger, Corinna, Mandel, Ronald J., Annett, Lucy, Kirik, Deniz
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2005
Schlagworte:
Neurobiology of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725622/
https://ncbi.nlm.nih.gov/pubmed/15673656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4421-04.2005
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