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Spinal G-Protein-Gated Potassium Channels Contribute in a Dose-Dependent Manner to the Analgesic Effect of μ- and δ- But Not κ-Opioids

Opioids can evoke analgesia by inhibiting neuronal targets in either the brain or spinal cord, and multiple presynaptic and postsynaptic inhibitory mechanisms have been implicated. The relative significance of presynaptic and postsynaptic inhibition to opioid analgesia is essentially unknown, as are...

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Pubblicato in:J Neurosci
Autori principali: Marker, Cheryl L., Luján, Rafael, Loh, Horace H., Wickman, Kevin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725379/
https://ncbi.nlm.nih.gov/pubmed/15814785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4899-04.2005
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