In Vivo Activation of a Mutant μ-Opioid Receptor by Naltrexone Produces a Potent Analgesic Effect But No Tolerance: Role of μ-Receptor Activation and δ-Receptor Blockade in Morphine Tolerance

Opioid analgesics are the standard therapeutic agents for the treatment of pain, but their prolonged use is limited because of the development of tolerance and dependence. Recently, we reported the development of a μ-opioid receptor knock-in (KI) mouse in which the μ-opioid receptor was replaced by...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Roy, Sabita, Guo, Xiaohong, Kelschenbach, Jennifer, Liu, Yuxiu, Loh, Horace H.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2005
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5764089/
https://ncbi.nlm.nih.gov/pubmed/15788780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0332-05.2005
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