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In Vivo Activation of a Mutant μ-Opioid Receptor by Naltrexone Produces a Potent Analgesic Effect But No Tolerance: Role of μ-Receptor Activation and δ-Receptor Blockade in Morphine Tolerance
Opioid analgesics are the standard therapeutic agents for the treatment of pain, but their prolonged use is limited because of the development of tolerance and dependence. Recently, we reported the development of a μ-opioid receptor knock-in (KI) mouse in which the μ-opioid receptor was replaced by...
Gespeichert in:
| Veröffentlicht in: | J Neurosci |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Society for Neuroscience
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5764089/ https://ncbi.nlm.nih.gov/pubmed/15788780 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0332-05.2005 |
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