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Single-Gene Deletions Contributing to Loss of Heterozygosity in Saccharomyces cerevisiae: Genome-Wide Screens and Reproducibility

Loss of heterozygosity (LOH) is a phenomenon commonly observed in cancers; the loss of chromosomal regions can be both causal and indicative of underlying genome instability. Yeast has long been used as a model organism to study genetic mechanisms difficult to study in mammalian cells. Studying gene...

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Bibliografiske detaljer
Udgivet i:G3 (Bethesda)
Main Authors: Hoffert, Kellyn M., Strome, Erin D.
Format: Artigo
Sprog:Inglês
Udgivet: Genetics Society of America 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6723133/
https://ncbi.nlm.nih.gov/pubmed/31270132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.119.400429
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