Human FcRn Tissue Expression Profile and Half-Life in PBMCs

System-wide quantitative characterization of human neonatal Fc receptor (FcRn) properties is critical for understanding and predicting human PK (pharmacokinetics) as well as the distribution of mAbs and Fc-fusion proteins using PBPK (physiologically-based pharmacokinetic) modeling. To this end, tiss...

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Detalhes bibliográficos
Publicado no:Biomolecules
Main Authors: Fan, Yao-Yun, Farrokhi, Vahid, Caiazzo, Teresa, Wang, Mengmeng, O’Hara, Denise M., Neubert, Hendrik
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6722552/
https://ncbi.nlm.nih.gov/pubmed/31443181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom9080373
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