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Phosphonate prodrugs: an overview and recent advances
Phosphonates, often used as isosteric replacements for phosphates, can provide important interactions with an enzyme. Due to their high charge at physiological pH, however, permeation into cells can be a challenge. Protecting phosphonates as prodrugs has shown promise in drug delivery. Thus, a varie...
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| Veröffentlicht in: | Future Med Chem |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Newlands Press Ltd
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6722485/ https://ncbi.nlm.nih.gov/pubmed/31469328 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc-2018-0591 |
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