Generation of Human iPSC–Derived Intestinal Epithelial Cell Monolayers by CDX2 Transduction

BACKGROUND & AIMS: To develop an effective and safe orally administered drug, it is important to predict its intestinal absorption rate, intestinal first-pass effect, and drug-drug interactions of orally administered drugs. However, there is no existing model to comprehensively predict the intes...

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Detalhes bibliográficos
Publicado no:Cell Mol Gastroenterol Hepatol
Main Authors: Takayama, Kazuo, Negoro, Ryosuke, Yamashita, Tomoki, Kawai, Kanae, Ichikawa, Moe, Mori, Takanori, Nakatsu, Noriyuki, Harada, Kazuo, Ito, Sumito, Yamada, Hiroshi, Yamaura, Yoshiyuki, Hirata, Kazumasa, Ishida, Seiichi, Mizuguchi, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6722387/
https://ncbi.nlm.nih.gov/pubmed/31228606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2019.06.004
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