Establishment of SLC15A1/PEPT1-Knockout Human-Induced Pluripotent Stem Cell Line for Intestinal Drug Absorption Studies

Because many peptide and peptide-mimetic drugs are substrates of peptide transporter 1, it is important to evaluate the peptide transporter 1-mediated intestinal absorption of drug candidates in the early phase of drug development. Although intestinal cell lines treated with inhibitors of peptide tr...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Kawai, Kanae, Negoro, Ryosuke, Ichikawa, Moe, Yamashita, Tomoki, Deguchi, Sayaka, Harada, Kazuo, Hirata, Kazumasa, Takayama, Kazuo, Mizuguchi, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6926248/
https://ncbi.nlm.nih.gov/pubmed/31890740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2019.11.008
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