Optimizing Modified mRNA In Vitro Synthesis Protocol for Heart Gene Therapy

Synthetic modified RNA (modRNA) is a novel vector for gene transfer to the heart and other organs. modRNA can mediate strong, transient protein expression with minimal induction of the innate immune response and risk for genome integration. modRNA is already being used in several human clinical tria...

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Vydáno v:Mol Ther Methods Clin Dev
Hlavní autoři: Hadas, Yoav, Sultana, Nishat, Youssef, Elias, Sharkar, Mohammad Tofael Kabir, Kaur, Keerat, Chepurko, Elena, Zangi, Lior
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6722299/
https://ncbi.nlm.nih.gov/pubmed/31508439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2019.07.006
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