Optimizing Modified mRNA In Vitro Synthesis Protocol for Heart Gene Therapy

Synthetic modified RNA (modRNA) is a novel vector for gene transfer to the heart and other organs. modRNA can mediate strong, transient protein expression with minimal induction of the innate immune response and risk for genome integration. modRNA is already being used in several human clinical tria...

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Bibliografske podrobnosti
izdano v:Mol Ther Methods Clin Dev
Main Authors: Hadas, Yoav, Sultana, Nishat, Youssef, Elias, Sharkar, Mohammad Tofael Kabir, Kaur, Keerat, Chepurko, Elena, Zangi, Lior
Format: Artigo
Jezik:Inglês
Izdano: American Society of Gene & Cell Therapy 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6722299/
https://ncbi.nlm.nih.gov/pubmed/31508439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2019.07.006
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