Therapeutic Delivery of Pip4k2c‐Modified mRNA Attenuates Cardiac Hypertrophy and Fibrosis in the Failing Heart

Heart failure (HF) remains a major cause of morbidity and mortality worldwide. One of the risk factors for HF is cardiac hypertrophy (CH), which is frequently accompanied by cardiac fibrosis (CF). CH and CF are controlled by master regulators mTORC1 and TGF‐β, respectively. Type‐2‐phosphatidylinosit...

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Опубликовано в: :Adv Sci (Weinh)
Главные авторы: Magadum, Ajit, Singh, Neha, Kurian, Ann Anu, Sharkar, Mohammad Tofael Kabir, Sultana, Nishat, Chepurko, Elena, Kaur, Keerat, Żak, Magdalena M., Hadas, Yoav, Lebeche, Djamel, Sahoo, Susmita, Hajjar, Roger, Zangi, Lior
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2021
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Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8132051/
https://ncbi.nlm.nih.gov/pubmed/34026458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.202004661
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