Therapeutic Delivery of Pip4k2c‐Modified mRNA Attenuates Cardiac Hypertrophy and Fibrosis in the Failing Heart

Heart failure (HF) remains a major cause of morbidity and mortality worldwide. One of the risk factors for HF is cardiac hypertrophy (CH), which is frequently accompanied by cardiac fibrosis (CF). CH and CF are controlled by master regulators mTORC1 and TGF‐β, respectively. Type‐2‐phosphatidylinosit...

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Foilsithe in:Adv Sci (Weinh)
Main Authors: Magadum, Ajit, Singh, Neha, Kurian, Ann Anu, Sharkar, Mohammad Tofael Kabir, Sultana, Nishat, Chepurko, Elena, Kaur, Keerat, Żak, Magdalena M., Hadas, Yoav, Lebeche, Djamel, Sahoo, Susmita, Hajjar, Roger, Zangi, Lior
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2021
Ábhair:
Research Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8132051/
https://ncbi.nlm.nih.gov/pubmed/34026458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.202004661
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