Therapeutic Delivery of Pip4k2c‐Modified mRNA Attenuates Cardiac Hypertrophy and Fibrosis in the Failing Heart

Heart failure (HF) remains a major cause of morbidity and mortality worldwide. One of the risk factors for HF is cardiac hypertrophy (CH), which is frequently accompanied by cardiac fibrosis (CF). CH and CF are controlled by master regulators mTORC1 and TGF‐β, respectively. Type‐2‐phosphatidylinosit...

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Detalles Bibliográficos
Publicado en:Adv Sci (Weinh)
Main Authors: Magadum, Ajit, Singh, Neha, Kurian, Ann Anu, Sharkar, Mohammad Tofael Kabir, Sultana, Nishat, Chepurko, Elena, Kaur, Keerat, Żak, Magdalena M., Hadas, Yoav, Lebeche, Djamel, Sahoo, Susmita, Hajjar, Roger, Zangi, Lior
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2021
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8132051/
https://ncbi.nlm.nih.gov/pubmed/34026458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.202004661
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