Optimizing Modified mRNA In Vitro Synthesis Protocol for Heart Gene Therapy

Synthetic modified RNA (modRNA) is a novel vector for gene transfer to the heart and other organs. modRNA can mediate strong, transient protein expression with minimal induction of the innate immune response and risk for genome integration. modRNA is already being used in several human clinical tria...

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Bibliografische gegevens
Gepubliceerd in:Mol Ther Methods Clin Dev
Hoofdauteurs: Hadas, Yoav, Sultana, Nishat, Youssef, Elias, Sharkar, Mohammad Tofael Kabir, Kaur, Keerat, Chepurko, Elena, Zangi, Lior
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Gene & Cell Therapy 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6722299/
https://ncbi.nlm.nih.gov/pubmed/31508439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2019.07.006
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