Expression Kinetics and Innate Immune Response after Electroporation and LNP-Mediated Delivery of a Self-Amplifying mRNA in the Skin

In this work, we studied the expression kinetics and innate immune response of a self-amplifying mRNA (sa-RNA) after electroporation and lipid-nanoparticle (LNP)-mediated delivery in the skin of mice. Intradermal electroporation of the sa-RNA resulted in a plateau-shaped expression, with the plateau...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Mol Ther Nucleic Acids
Hauptverfasser: Huysmans, Hanne, Zhong, Zifu, De Temmerman, Joyca, Mui, Barbara L., Tam, Ying K., Mc Cafferty, Séan, Gitsels, Arlieke, Vanrompay, Daisy, Sanders, Niek N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2019
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6722285/
https://ncbi.nlm.nih.gov/pubmed/31472371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2019.08.001
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge