Expression Kinetics and Innate Immune Response after Electroporation and LNP-Mediated Delivery of a Self-Amplifying mRNA in the Skin

In this work, we studied the expression kinetics and innate immune response of a self-amplifying mRNA (sa-RNA) after electroporation and lipid-nanoparticle (LNP)-mediated delivery in the skin of mice. Intradermal electroporation of the sa-RNA resulted in a plateau-shaped expression, with the plateau...

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Pubblicato in:Mol Ther Nucleic Acids
Autori principali: Huysmans, Hanne, Zhong, Zifu, De Temmerman, Joyca, Mui, Barbara L., Tam, Ying K., Mc Cafferty, Séan, Gitsels, Arlieke, Vanrompay, Daisy, Sanders, Niek N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6722285/
https://ncbi.nlm.nih.gov/pubmed/31472371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2019.08.001
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