In Vivo Validation of a Reversible Small Molecule-Based Switch for Synthetic Self-Amplifying mRNA Regulation

Synthetic mRNA therapeutics have the potential to revolutionize healthcare, as they enable patients to produce therapeutic proteins inside their own bodies. However, convenient methods that allow external control over the timing and magnitude of protein production after in vivo delivery of synthetic...

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Detalhes bibliográficos
Publicado no:Mol Ther
Principais autores: Mc Cafferty, Sean, De Temmerman, Joyca, Kitada, Tasuku, Becraft, Jacob R., Weiss, Ron, Irvine, Darrell J., Devreese, Mathias, De Baere, Siegrid, Combes, Francis, Sanders, Niek N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2021
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7934578/
https://ncbi.nlm.nih.gov/pubmed/33186690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.11.010
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