Ligand Binding Dynamics for Pre-dimerised G Protein-Coupled Receptor Homodimers: Linear Models and Analytical Solutions

Evidence suggests that many G protein-coupled receptors (GPCRs) are bound together forming dimers. The implications of dimerisation for cellular signalling outcomes, and ultimately drug discovery and therapeutics, remain unclear. Consideration of ligand binding and signalling via receptor dimers is...

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Udgivet i:Bull Math Biol
Main Authors: White, Carla, Bridge, Lloyd J.
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2018
Fag:
Special Issue: Mathematics to Support Drug Discovery and Development
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6722261/
https://ncbi.nlm.nih.gov/pubmed/29349610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11538-017-0387-x
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