Notch-1 Inhibition Promotes Immune Regulation in Transplantation via Treg-Dependent Mechanisms

BACKGROUND: Transplantation is the treatment of choice for many patients with end-stage organ disease. Despite advances in immunosuppression, long-term outcomes remain suboptimal, hampered by drug toxicity and immune-mediated injury, the leading cause of late graft loss. The development of therapies...

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Detalhes bibliográficos
Publicado no:Circulation
Main Authors: Magee, Ciara N., Murakami, Naoka, Borges, Thiago J., Shimizu, Tetsunosuke, Safa, Kassem, Ohori, Shunsuke, Cai, Songjie, Uffing, Audrey, Azzi, Jamil, Elyaman, Wassim, Charbonnier, Louis-Marie, Liu, Kaifeng, Toprak, Demet, Visner, Gary, Chatila, Talal A., Siebel, Christian W., Najafian, Nader, Riella, Leonardo V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6722011/
https://ncbi.nlm.nih.gov/pubmed/31266349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.119.040563
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