Isomerization of Asp7 in Beta-Amyloid Enhances Inhibition of the α7 Nicotinic Receptor and Promotes Neurotoxicity

Cholinergic dysfunction in Alzheimer’s disease (AD) can be mediated by the neuronal α7 nicotinic acetylcholine receptor (α7nAChR). Beta-amyloid peptide (Aβ) binds to the α7nAChR, disrupting the receptor’s function and causing neurotoxicity. In vivo not only Aβ but also its modified forms can drive A...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cells
Main Authors: Barykin, Evgeny P., Garifulina, Alexandra I., Kruykova, Elena V., Spirova, Ekaterina N., Anashkina, Anastasia A., Adzhubei, Alexei A., Shelukhina, Irina V., Kasheverov, Igor E., Mitkevich, Vladimir A., Kozin, Sergey A., Hollmann, Michael, Tsetlin, Victor I., Makarov, Alexander A.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6721525/
https://ncbi.nlm.nih.gov/pubmed/31349637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8080771
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados