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GSK3-β Stimulates Claspin Degradation via β-TrCP Ubiquitin Ligase and Alters Cancer Cell Survival

Claspin is essential for activating the DNA damage checkpoint effector kinase Chk1, a target in oncotherapy. Claspin functions are tightly correlated to Claspin protein stability, regulated by ubiquitin-dependent proteasomal degradation. Here we identify Glycogen Synthase Kinase 3-β (GSK3-β) as a ne...

詳細記述

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書誌詳細
出版年:Cancers (Basel)
主要な著者: Cabrera, Elisa, Raninga, Prahlad, Khanna, Kum Kum, Freire, Raimundo
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6721324/
https://ncbi.nlm.nih.gov/pubmed/31362447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11081073
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