Identification and Characterization of Mutations in Ubiquitin Required for Non-covalent Dimer Formation

Ubiquitin (Ub) is a small protein that post-translationally modifies a variety of substrates in eukaryotic cells to modulate substrate function. The ability of Ub to interact with numerous protein domains makes Ub an attractive scaffold for engineering ubiquitin variants (UbVs) with high target spec...

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Bibliographic Details
Published in:Structure
Main Authors: Gabrielsen, Mads, Buetow, Lori, Kowalczyk, Dominika, Zhang, Wei, Sidhu, Sachdev S., Huang, Danny T.
Format: Artigo
Language:Inglês
Published: Cell Press 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6720194/
https://ncbi.nlm.nih.gov/pubmed/31303481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2019.06.008
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