A cohesin/HUSH- and LINC-dependent pathway controls ribosomal DNA double-strand break repair

The ribosomal DNA (rDNA) represents a particularly unstable locus undergoing frequent breakage. DNA double-strand breaks (DSBs) within rDNA induce both rDNA transcriptional repression and nucleolar segregation, but the link between the two events remains unclear. Here we found that DSBs induced on r...

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Détails bibliographiques
Publié dans:Genes Dev
Auteurs principaux: Marnef, Aline, Finoux, Anne-Laure, Arnould, Coline, Guillou, Emmanuelle, Daburon, Virginie, Rocher, Vincent, Mangeat, Thomas, Mangeot, Philippe E., Ricci, Emiliano P., Legube, Gaëlle
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2019
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6719620/
https://ncbi.nlm.nih.gov/pubmed/31395742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.324012.119
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