Loop extrusion as a mechanism for DNA damage repair foci formation

DNA Double-Strand Break (DSB) repair is essential to safeguard genome integrity. Upon DSBs, the ATM PI3K kinase rapidly triggers the establishment of megabase-sized, γH2AX-decorated chromatin domains which further act as seeds for the formation of DNA Damage Response (DDR) foci(1). How these foci ar...

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Publicado no:Nature
Main Authors: Arnould, Coline, Rocher, Vincent, Finoux, Anne-Laure, Clouaire, Thomas, Li, Kevin, Zhou, Felix, Caron, Pierre, Mangeot, Philippe. E., Ricci, Emiliano P., Mourad, Raphael, Haber, James E, Noordermeer, Daan, Legube, Gaëlle
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116834/
https://ncbi.nlm.nih.gov/pubmed/33597753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-021-03193-z
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