Best practices and benchmarks for intact protein analysis for top-down mass spectrometry

One gene can give rise to many functionally distinct proteoforms, each of which has a characteristic molecular mass. Top-down mass spectrometry enables the analysis of intact proteins and proteoforms. Here members of the Consortium for Top-Down Proteomics provide a decision tree that guides research...

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Vydáno v:Nat Methods
Hlavní autoři: Donnelly, Daniel P., Rawlins, Catherine M., DeHart, Caroline J., Fornelli, Luca, Schachner, Luis F., Lin, Ziqing, Lippens, Jennifer L., Aluri, Krishna C., Sarin, Richa, Chen, Bifan, Lantz, Carter, Jung, Wonhyeuk, Johnson, Kendall R., Koller, Antonius, Wolff, Jeremy J., Campuzano, Iain D. G., Auclair, Jared R., Ivanov, Alexander R., Whitelegge, Julian P., Paša-Tolić, Ljiljana, Chamot-Rooke, Julia, Danis, Paul O., Smith, Lloyd M., Tsybin, Yury O., Loo, Joseph A., Ge, Ying, Kelleher, Neil L., Agar, Jeffrey N.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group US 2019
Témata:
Perspective
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6719561/
https://ncbi.nlm.nih.gov/pubmed/31249407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41592-019-0457-0
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