Metalloprotease inhibitor TIMP proteins control FGF-2 bioavailability and regulate skeletal growth

Regulated growth plate activity is essential for postnatal bone development and body stature, yet the systems regulating epiphyseal fusion are poorly understood. Here, we show that the tissue inhibitors of metalloprotease (TIMP) gene family is essential for normal bone growth after birth. Whole-body...

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Опубликовано в: :J Cell Biol
Главные авторы: Saw, Sanjay, Aiken, Alison, Fang, Hui, McKee, Trevor D., Bregant, Sarah, Sanchez, Otto, Chen, Yan, Weiss, Ashley, Dickson, Brendan C., Czarny, Bertrand, Sinha, Ankit, Fosang, Amanda, Dive, Vincent, Waterhouse, Paul D., Kislinger, Thomas, Khokha, Rama
Формат: Artigo
Язык:Inglês
Опубликовано: Rockefeller University Press 2019
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6719459/
https://ncbi.nlm.nih.gov/pubmed/31371388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201906059
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