Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid–induced mTORC1 signaling

Retromer is an evolutionarily conserved multiprotein complex that orchestrates the endocytic recycling of integral membrane proteins. Here, we demonstrate that retromer is also required to maintain lysosomal amino acid signaling through mTORC1 across species. Without retromer, amino acids no longer...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Kvainickas, Arunas, Nägele, Heike, Qi, Wenjing, Dokládal, Ladislav, Jimenez-Orgaz, Ana, Stehl, Luca, Gangurde, Dipak, Zhao, Qian, Hu, Zehan, Dengjel, Jörn, De Virgilio, Claudio, Baumeister, Ralf, Steinberg, Florian
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6719456/
https://ncbi.nlm.nih.gov/pubmed/31431476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201812110
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