GPBAR1 Functions as Gatekeeper for Liver NKT Cells and provides Counterregulatory Signals in Mouse Models of Immune-Mediated Hepatitis

BACKGROUND & AIMS: GPBAR1, also known as TGR5, is a G protein–coupled receptor activated by bile acids. Hepatic innate immune cells are involved in the immunopathogenesis of human liver diseases and in several murine hepatitis models. Here, by using genetic and pharmacological approaches, we pro...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Mol Gastroenterol Hepatol
Auteurs principaux: Biagioli, Michele, Carino, Adriana, Fiorucci, Chiara, Marchianò, Silvia, Di Giorgio, Cristina, Roselli, Rosalinda, Magro, Margherita, Distrutti, Eleonora, Bereshchenko, Oxana, Scarpelli, Paolo, Zampella, Angela, Fiorucci, Stefano
Format: Artigo
Langue:Inglês
Publié: Elsevier 2019
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718949/
https://ncbi.nlm.nih.gov/pubmed/31226434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2019.06.003
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