GPBAR1 Functions as Gatekeeper for Liver NKT Cells and provides Counterregulatory Signals in Mouse Models of Immune-Mediated Hepatitis

BACKGROUND & AIMS: GPBAR1, also known as TGR5, is a G protein–coupled receptor activated by bile acids. Hepatic innate immune cells are involved in the immunopathogenesis of human liver diseases and in several murine hepatitis models. Here, by using genetic and pharmacological approaches, we pro...

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Veröffentlicht in:Cell Mol Gastroenterol Hepatol
Hauptverfasser: Biagioli, Michele, Carino, Adriana, Fiorucci, Chiara, Marchianò, Silvia, Di Giorgio, Cristina, Roselli, Rosalinda, Magro, Margherita, Distrutti, Eleonora, Bereshchenko, Oxana, Scarpelli, Paolo, Zampella, Angela, Fiorucci, Stefano
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2019
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718949/
https://ncbi.nlm.nih.gov/pubmed/31226434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2019.06.003
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