GPBAR1 Functions as Gatekeeper for Liver NKT Cells and provides Counterregulatory Signals in Mouse Models of Immune-Mediated Hepatitis

BACKGROUND & AIMS: GPBAR1, also known as TGR5, is a G protein–coupled receptor activated by bile acids. Hepatic innate immune cells are involved in the immunopathogenesis of human liver diseases and in several murine hepatitis models. Here, by using genetic and pharmacological approaches, we pro...

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Detalhes bibliográficos
Publicado no:Cell Mol Gastroenterol Hepatol
Main Authors: Biagioli, Michele, Carino, Adriana, Fiorucci, Chiara, Marchianò, Silvia, Di Giorgio, Cristina, Roselli, Rosalinda, Magro, Margherita, Distrutti, Eleonora, Bereshchenko, Oxana, Scarpelli, Paolo, Zampella, Angela, Fiorucci, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718949/
https://ncbi.nlm.nih.gov/pubmed/31226434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2019.06.003
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