UCP2 Deficiency Increases Colon Tumorigenesis by Promoting Lipid Synthesis and Depleting NADPH for Antioxidant Defenses

Colorectal cancer (CRC) is associated with metabolic and redox perturbation. The mitochondrial transporter uncoupling protein 2 (UCP2) controls cell proliferation in vitro through the modulation of cellular metabolism, but the underlying mechanism in tumors in vivo remains unexplored. Using murine i...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Aguilar, Esther, Esteves, Pauline, Sancerni, Tiphaine, Lenoir, Véronique, Aparicio, Thomas, Bouillaud, Frédéric, Dentin, Renaud, Prip-Buus, Carina, Ricquier, Daniel, Pecqueur, Claire, Guilmeau, Sandra, Alves-Guerra, Marie-Clotilde
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718829/
https://ncbi.nlm.nih.gov/pubmed/31461648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.07.097
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