FXR overexpression alters adipose tissue architecture in mice and limits its storage capacity leading to metabolic derangements

The bile acid-activated nuclear receptor, FXR (NR1H4), has been implicated in the control of lipid and energy metabolism, but its role in fat tissue, where it is moderately expressed, is not understood. In view of the recent development of FXR-targeting therapeutics for treatment of human metabolic...

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Vydáno v:J Lipid Res
Hlavní autoři: van Zutphen, Tim, Stroeve, Johanna H. M., Yang, Jiufang, Bloks, Vincent W., Jurdzinski, Angelika, Roelofsen, Han, Huijkman, Nicolette C. A., van Dijk, Theo H., Vonk, Roel J., van Deursen, Jan, Staels, Bart, Groen, Albert K., Kuipers, Folkert
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718433/
https://ncbi.nlm.nih.gov/pubmed/31253637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M094508
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