Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element

Serum levels of HDL are inversely correlated with the risk of coronary heart disease. The anti-atherogenic effect of HDL is partially mediated by its major protein constituent apoA-I. In this study, we identify bile acids that are activators of the nuclear receptor farnesoid X receptor (FXR) as nega...

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Autori principali: Claudel, Thierry, Sturm, Ekkehard, Duez, Hélène, Torra, Inés Pineda, Sirvent, Audrey, Kosykh, Vladimir, Fruchart, Jean-Charles, Dallongeville, Jean, Hum, Dean W., Kuipers, Folkert, Staels, Bart
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2002
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC150929/
https://ncbi.nlm.nih.gov/pubmed/11927623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI14505
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