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Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element

Serum levels of HDL are inversely correlated with the risk of coronary heart disease. The anti-atherogenic effect of HDL is partially mediated by its major protein constituent apoA-I. In this study, we identify bile acids that are activators of the nuclear receptor farnesoid X receptor (FXR) as nega...

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Vydáno v:J Clin Invest
Hlavní autoři: Claudel, Thierry, Sturm, Ekkehard, Duez, Hélène, Torra, Inés Pineda, Sirvent, Audrey, Kosykh, Vladimir, Fruchart, Jean-Charles, Dallongeville, Jean, Hum, Dean W., Kuipers, Folkert, Staels, Bart
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2002
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC150929/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11927623/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI14505
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