Benzoyl Indoles with Metabolic Stability as Reversal Agents for ABCG2-Mediated Multidrug Resistance

Ko143, a potent ABCG2 inhibitor that reverses multidrug resistance, cannot be used clinically due to its unsuitable metabolic stability. We identified benzoyl indoles as reversal agents that reversed ABCG2-mediated multidrug resistance (MDR), with synthetic tractability and enhanced metabolic stabil...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Eur J Med Chem
Egile Nagusiak: Cai, Chao-Yun, Zhai, Hong, Lei, Zi-Ning, Tan, Cai-Ping, Chen, Bao-Li, Du, Zhao-Yi, Wang, Jing-Quan, Zhang, Yun-Kai, Wang, Yi-Jun, Gupta, Pranav, Wang, Bo, Chen, Zhe-Sheng
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718313/
https://ncbi.nlm.nih.gov/pubmed/31302589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2019.06.066
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