Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells

Overexpression of ATP-binding cassette (ABC) transporters is one of the most important mechanisms responsible for the development of multidrug resistance (MDR). Selonsertib, a serine/threonine kinase inhibitor, targets apoptosis signal-regulating kinase 1 (ASK1) and is now in phase III clinical tria...

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Dades bibliogràfiques
Publicat a:Cancer Lett
Autors principals: Ji, Ning, Yang, Yuqi, Cai, Chao-Yun, Lei, Zi-Ning, Wang, Jing-Quan, Gupta, Pranav, Shukla, Suneet, Ambudkar, Suresh V., Kong, Dexin, Chen, Zhe-Sheng
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8132112/
https://ncbi.nlm.nih.gov/pubmed/30315846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2018.10.007
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