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Combinatorial biosynthesis and the basis for substrate promiscuity in class I diterpene synthases

Terpene synthases are capable of mediating complex reactions, but fundamentally simply catalyze lysis of allylic diphosphate esters with subsequent deprotonation. Even with the initially generated tertiary carbocation this offers a variety of product outcomes, and deprotonation further can be preced...

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Vydáno v:Metab Eng
Hlavní autoři: Jia, Meirong, Mishra, Sambit K., Tufts, Samuel, Jernigan, Robert L., Peters, Reuben J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6717049/
https://ncbi.nlm.nih.gov/pubmed/31220664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymben.2019.06.008
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