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Probing the promiscuity of ent-kaurene oxidases via combinatorial biosynthesis

The substrate specificity of enzymes from natural products’ metabolism is a topic of considerable interest, with potential biotechnological use implicit in the discovery of promiscuous enzymes. However, such studies are often limited by the availability of substrates and authentic standards for iden...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Mafu, Sibongile, Jia, Meirong, Zi, Jiachen, Morrone, Dana, Wu, Yisheng, Xu, Meimei, Hillwig, Matthew L., Peters, Reuben J.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780596/
https://ncbi.nlm.nih.gov/pubmed/26884192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1512096113
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