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Identification of somatic mutations in single cell DNA-seq using a spatial model of allelic imbalance

Recent advances in single cell technology have enabled dissection of cellular heterogeneity in great detail. However, analysis of single cell DNA sequencing data remains challenging due to bias and artifacts that arise during DNA extraction and whole-genome amplification, including allelic imbalance...

詳細記述

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書誌詳細
出版年:Nat Commun
主要な著者: Luquette, Lovelace J., Bohrson, Craig L., Sherman, Max A., Park, Peter J.
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6715686/
https://ncbi.nlm.nih.gov/pubmed/31467286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11857-8
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