Somatic mutation in single human neurons tracks developmental and transcriptional history

Neurons live for decades in a postmitotic state, their genomes susceptible to DNA damage. Here we survey the landscape of somatic single-nucleotide variants (SNVs) in the human brain. We identified thousands of somatic SNVs by single-cell sequencing of 36 neurons from the cerebral cortex of three no...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Lodato, Michael A., Woodworth, Mollie B., Lee, Semin, Evrony, Gilad D., Mehta, Bhaven K., Karger, Amir, Lee, Soohyun, Chittenden, Thomas W., D’Gama, Alissa M., Cai, Xuyu, Luquette, Lovelace J., Lee, Eunjung, Park, Peter J., Walsh, Christopher A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664477/
https://ncbi.nlm.nih.gov/pubmed/26430121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aab1785
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