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Somatic mutation in single human neurons tracks developmental and transcriptional history

Neurons live for decades in a postmitotic state, their genomes susceptible to DNA damage. Here we survey the landscape of somatic single-nucleotide variants (SNVs) in the human brain. We identified thousands of somatic SNVs by single-cell sequencing of 36 neurons from the cerebral cortex of three no...

詳細記述

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書誌詳細
出版年:Science
主要な著者: Lodato, Michael A., Woodworth, Mollie B., Lee, Semin, Evrony, Gilad D., Mehta, Bhaven K., Karger, Amir, Lee, Soohyun, Chittenden, Thomas W., D’Gama, Alissa M., Cai, Xuyu, Luquette, Lovelace J., Lee, Eunjung, Park, Peter J., Walsh, Christopher A.
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664477/
https://ncbi.nlm.nih.gov/pubmed/26430121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aab1785
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