Variation in a Left Ventricle-Specific Hand1 Enhancer Impairs GATA Transcription Factor Binding and Disrupts Conduction System Development and Function

RATIONALE: The ventricular conduction system (VCS) rapidly propagates electrical impulses through the working myocardium of the ventricles to coordinate chamber contraction. Genome-wide association studies (GWAS) have associated nucleotide polymorphisms, most are located within regulatory intergenic...

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Publicat a:Circ Res
Autors principals: Vincentz, Joshua W., Firulli, Beth A., Toolan, Kevin P., Arking, Dan E., Sotoodehnia, Nona, Wan, Juyi, Chen, Peng-Sheng, de Gier-de Vries, Corrie, Christoffels, Vincent M., Rubart-von der Lohe, Michael, Firulli, Anthony B.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6715539/
https://ncbi.nlm.nih.gov/pubmed/31366290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.119.315313
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