Rbfox1 up-regulation impairs BDNF-dependent hippocampal LTP by dysregulating TrkB isoform expression levels

Brain-derived neurotrophic factor (BDNF) is a potent modulator of brain synaptic plasticity. Signaling defects caused by dysregulation of its Ntrk2 (TrkB) kinase (TrkB.FL) and truncated receptors (TrkB.T1) have been linked to the pathophysiology of several neurological and neurodegenerative disorder...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Tomassoni-Ardori, Francesco, Fulgenzi, Gianluca, Becker, Jodi, Barrick, Colleen, Palko, Mary Ellen, Kuhn, Skyler, Koparde, Vishal, Cam, Maggie, Yanpallewar, Sudhirkumar, Oberdoerffer, Shalini, Tessarollo, Lino
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2019
Matèries:
Neuroscience
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6715404/
https://ncbi.nlm.nih.gov/pubmed/31429825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.49673
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