Rbfox1 up-regulation impairs BDNF-dependent hippocampal LTP by dysregulating TrkB isoform expression levels

Brain-derived neurotrophic factor (BDNF) is a potent modulator of brain synaptic plasticity. Signaling defects caused by dysregulation of its Ntrk2 (TrkB) kinase (TrkB.FL) and truncated receptors (TrkB.T1) have been linked to the pathophysiology of several neurological and neurodegenerative disorder...

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Udgivet i:eLife
Main Authors: Tomassoni-Ardori, Francesco, Fulgenzi, Gianluca, Becker, Jodi, Barrick, Colleen, Palko, Mary Ellen, Kuhn, Skyler, Koparde, Vishal, Cam, Maggie, Yanpallewar, Sudhirkumar, Oberdoerffer, Shalini, Tessarollo, Lino
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2019
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6715404/
https://ncbi.nlm.nih.gov/pubmed/31429825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.49673
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