Novel metabolic role for BDNF in pancreatic β-cell insulin secretion

BDNF signaling in hypothalamic circuitries regulates mammalian food intake. However, whether BDNF exerts metabolic effects on peripheral organs is currently unknown. Here, we show that the BDNF receptor TrkB.T1 is expressed by pancreatic β-cells where it regulates insulin release. Mice lacking TrkB....

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Fulgenzi, Gianluca, Hong, Zhenyi, Tomassoni-Ardori, Francesco, Barella, Luiz F., Becker, Jodi, Barrick, Colleen, Swing, Deborah, Yanpallewar, Sudhirkumar, Croix, Brad St, Wess, Jürgen, Gavrilova, Oksana, Tessarollo, Lino
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181656/
https://ncbi.nlm.nih.gov/pubmed/32327658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15833-5
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