Novel metabolic role for BDNF in pancreatic β-cell insulin secretion

BDNF signaling in hypothalamic circuitries regulates mammalian food intake. However, whether BDNF exerts metabolic effects on peripheral organs is currently unknown. Here, we show that the BDNF receptor TrkB.T1 is expressed by pancreatic β-cells where it regulates insulin release. Mice lacking TrkB....

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Publicado en:Nat Commun
Main Authors: Fulgenzi, Gianluca, Hong, Zhenyi, Tomassoni-Ardori, Francesco, Barella, Luiz F., Becker, Jodi, Barrick, Colleen, Swing, Deborah, Yanpallewar, Sudhirkumar, Croix, Brad St, Wess, Jürgen, Gavrilova, Oksana, Tessarollo, Lino
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181656/
https://ncbi.nlm.nih.gov/pubmed/32327658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15833-5
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