PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice

Palmitic acid esters of hydroxy stearic acids (PAHSAs) are endogenous antidiabetic and antiinflammatory lipids. Here, we show that PAHSAs protect against type 1 diabetes (T1D) and promote β cell survival and function. Daily oral PAHSA administration to nonobese diabetic (NOD) mice delayed the onset...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Clin Invest
Prif Awduron: Syed, Ismail, Rubin de Celis, Maria F., Mohan, James F., Moraes-Vieira, Pedro M., Vijayakumar, Archana, Nelson, Andrew T., Siegel, Dionicio, Saghatelian, Alan, Mathis, Diane, Kahn, Barbara B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2019
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6715391/
https://ncbi.nlm.nih.gov/pubmed/31380811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI122445
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